Breast
Female breast cancer diagnosed ≤45.
Female breast cancer diagnosed age 46 to 50 if limited or unknown family history, multiple primary breast cancers, or >1 close blood relative with breast, ovarian, pancreatic, or prostate cancer diagnosed at any age.
Female breast cancer diagnosed age >51 with >1 close blood relative with any of the following: breast cancer age ≤50 or male breast cancer; ovarian cancer; exocrine pancreatic cancer; or metastatic prostate cancer, intraductal cribriform histology, and high-risk prostate cancer; or three total diagnoses of breast cancer in patient and/or close blood relatives.
Triple-negative breast cancer, any age.
Breast cancer diagnosed at any age if genetic testing would affect recommendations for PARP inhibitors (e.g., for metastatic patients or those with high-risk, HER2-negative breast cancer).
Invasive lobular breast cancer with personal or family history of diffuse gastric cancer.
Male breast cancer, any age.
Ovary
Invasive ovarian or fallopian tube cancer, or primary peritoneal cancer, any age
Prostate
Metastatic prostate cancer, intraductal/cribriform histology, and high-risk prostate cancer, any age.
Pancreas
Exocrine pancreatic cancer, any age.
Other
BRCA1/2 or other specific pathogenic variant identified from tumour genomic analysis, regardless of tumour type, if high suspicion for germline origin and confirmation of germline status has clinical implications for the patient or family members.
Those in whom a pathogenic variant in an actionable gene such as BRCA1/2 (or other high- to moderate-risk genes)has been identified in a biologic relative.
Those with a first-degree relative of an individual who meets the criteria above.
Those with clusters of genetically related cancers in two or more blood relatives (on the same side of the family if appropriate), such as breast and prostate cancer, or breast and pancreatic cancer
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